A man from the Truro area was seriously injured and transferred to Derriford Hospital's intensive care unit after his Volvo was in collision with a Seat van on the A30 near Bodmin on Monday night.
The accident happened just after 8pm at Preeze Cross between Bodmin and Temple and the Volvo driver, a man in his 30s, suffered serious head injuries.
The westbound carriageway was closed for more than four hours as police, an ambulance crew and firefighters from Bodmin and Launceston were called to the scene.
Police are appealing for witness to the collision and they should phone 101 and quote log number 681.