Thieves have stolen and defaced irreplaceable artwork at the Fish Factory Art Space during a break in.
Some of the work was part of an exhibition to raise money and awareness for Amnesty International at the site at Falmouth Wharves.
The incident happened between 9pm and 2am on April 19 when the building was broken into.
A number of other pieces, along with art supplies and personal belongings were taken from the studio spaces used by a number of artists.
And an unfinished painting was written on.
Art Space owner Ruth Hatcher said: "That was someone's work in progress, a very personal thing.
"It is upsetting for all concerned, largely because these things cannot be replaced.
"People put a log of time and effort into them. They are about serious issues that are very personal to the artists.
"It is just devastating. The artists are angry and upset. They just want their stuff back."
Police say there was a party taking place that night in a nearby building and some people were refused entry, but are keeping an open mind as to who is responsible for the crime.
Ms Hatcher added: "We would like to appeal for the return of the artwork - it's value at retail is unimportant but the time and thought put in by the artists is irreplaceable.
A number of objects and sculptures taken belong to artist Helen Owen and were part of the Art for Amnesty exhibition, highlighting the horrors of forced female circumcision.
She said: "I hope my work makes people stop and look. I'm told it is dark and disturbing.
"The series of work evolved from hearing and reading women's accounts of their own circumcisions. I was filled with horror, anger and fear.
The pieces include Three Feminine Sorrows which are three pieces of 10" to 16" length and 10" width made of latex and cloth, Mutilation, seven pieces average size 7" by 4" and Open, a book made from cloth and latex.
There were also four quirky ceramic sculptures created by Kate Merry taken and three smashed.
Anyone with information is asked to contact Falmouth police on 101 quoting reference GP13/ 760.
