A public vote against rival category contenders; Devon, Durham, Lancashire, Northumberland and Pembrokeshire, is now all that stands between the Duchy and the coveted top spot.
To help Cornwall defend its title, everyone with a love for the region is being urged to show it at www.vote4cornwall.com.
"I have always known that Cornwall is a premier UK destination with a premier offering, but the fact that we are in the running to be awarded best staycation destination for a sixth year, and that it is voted for by the general public, makes me feel incredibly proud," explains Malcolm Bell, Head of Visit Cornwall, the Cornwall Development Company tourism service.
"I am calling on everyone, from local businesses and residents, to loyal and new visitors, to vote and spread the word. Let's help Cornwall keep the title it deserves."
He added: "The winner now lies in the hands of the general public … love Cornwall, vote Cornwall."
In addition to being shortlisted for the top destination award, Cornwall also has a number of local businesses being recognised in other award categories.
For a second year, Bude is up for the title of Best UK Coastal Resort while the National Maritime Museum Cornwall and Eden Project are contenders for Heritage Attraction and Leisure Attraction respectively.
Julian German, Cornwall Council Portfolio Holder for Economy and Culture, adds: "This award shortlisting recognises excellence in Cornwall tourism. Each and every person involved in the sector is part of Cornwall's success and I sincerely hope their hard work, as well as that of those individual businesses flying the flag for Cornwall, is rewarded in this year's British Travel Awards."
Voting closes at the end of September and the winners will be announced at a glittering ceremony on 26 November at the Battersea Evolution in Battersea Park, London.
You can help Cornwall win by voting at www.vote4cornwall.com.